Separation of immiscible liquids using microfluidics

Document Type : Research paper

Authors

1 Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran

2 Department of Chemical and Petroleum engineering, Sharif University of Technology

Abstract

In this study, the continuous separation of hexane and water in micro-systems was investigated. For this purpose, two dimensional glass microfluidic chips were fabricated using laser ablation and thermal bonding method. The chips comprised of a main microchannel and few lateral micro channels. It was aimed to exit hexane and water from the, respectively, main and lateral micro channels. It was found that decreasing the width and increasing the number of the lateral micro channels, and increasing the flow rate of water result in increased separation. Also, increasing the flow rate of hexane and increasing the length of the lateral micro channels result in the reduction of the separation. In order to increase the operating flow rate of the capillary separation, three-dimensional microfluidic chips were fabricated by parallelization of four microscale capillary separators. With the three-dimensional microfluidic chips, the separation efficiency of up to 60% was achieved at the operating flow rate of 1.5 mL min-1.


 

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[1]           G. M. Whitesides, "The origins and the future of microfluidics," Nature, vol. 442, pp. 368-373, 07/27/print 2006.
[2]           M. A. Burns, B. N. Johnson, S. N. Brahmasandra, K. Handique, J. R. Webster, and M. Krishnan, "An Integrated Nanoliter DNA Analysis Device," Science, vol. 282, pp. 484-487, 1998.
[3]           T. Thorsen, S. J. Maerkl, and S. R. Quake, "Microfluidic Large-Scale Integration," Science, vol. 298, pp. 580-584, 2002.
[4]           C. F. Bucholz, D. Verhalten, and A. Schwefel, "Ges¨attigten, Aufl¨osung des Salpetersauren Urans  und des Wassers  zu dem Uran Haltigen  Schwefel¨ather," Neues allgem Journal der Chemie, vol. 4, pp. 134–160, 1805.
[5]           D. S. Flett, "Solvent extraction in hydrometallurgy: the role of organophosphorus extractants," Journal of Organometallic Chemistry, vol. 690, pp. 2426-2438, 5/16/ 2005.
[6]           G. Skarnemark, "Solvent Extraction and Ion Exchange in Radiochemistry," in Handbook of Nuclear Chemistry, A. Vértes, S. Nagy, Z. Klencsár, R. Lovas, and F. Rösch, Eds., ed: Springer US, 2011, pp. 2403-2428.
[7]           S. E. Kentish and G. W. Stevens, "Innovations in separations technology for the recycling and re-use of liquid waste streams," Chemical Engineering Journal, vol. 84, pp. 149-159, 10/15/ 2001.
[8]           M. N. Kashid, Y. M. Harshe, and D. W. Agar, "Liquid−Liquid Slug Flow in a Capillary:  An Alternative to Suspended Drop or Film Contactors," Industrial & Engineering Chemistry Research, vol. 46, pp. 8420-8430, 2007/12/01 2007.
[9]           J. P. Brody and P. Yager, "Diffusion-based extraction in a microfabricated device," Sensors and Actuators A: Physical, vol. 58, pp. 13-18, 1// 1997.
[10]         T. Sato K, M. okeshi, T. Sawada, and K. T, "Molecular transport between two phases in a microchannel.," Anal Sci, vol. 16, pp. 455-456, 2000.
[11]         M. Tokeshi and T. Kitamori, "Solvent extraction on chips, in Handbook of Capillary andMicrochip Electrophoresis and Associated Microtechniques," CRC Press, pp. 1021-1035, 2007.
[12]         P. Žnidaršič-Plazl and I. Plazl, "Steroid extraction in a microchannel system—mathematical modelling and experiments," Lab on a Chip, vol. 7, pp. 883-889, 2007.
[13]         H. Miyaguchi, M. Tokeshi, Y. Kikutani, A. Hibara, H. Inoue, and T. Kitamori, "Microchip-based liquid–liquid extraction for gas-chromatography analysis of amphetamine-type stimulants in urine," Journal of Chromatography A, vol. 1129, pp. 105-110, 2006.
[14]         P. Kuban, J. Berg, and P. K. Dasgupta, "Vertically stratified flows in microchannels. Computational simulations and applications to solvent extraction and ion exchange," Analytical chemistry, vol. 75, pp. 3549-3556, 2003.
[15]         S. Bowden, P. Monaghan, R. Wilson, J. Parnell, and J. Cooper, "The liquid–liquid diffusive extraction of hydrocarbons from a North Sea oil using a microfluidic format," Lab on a Chip, vol. 6, pp. 740-743, 2006.
[16]         T. Maruyama, H. Matsushita, J.-i. Uchida, F. Kubota, N. Kamiya, and M. Goto, "Liquid membrane operations in a microfluidic device for selective separation of metal ions," Analytical chemistry, vol. 76, pp. 4495-4500, 2004.
[17]         M. Kashid, Y. Harshe, and D. W. Agar, "Liquid− liquid slug flow in a capillary: an alternative to suspended drop or film contactors," Industrial & Engineering Chemistry Research, vol. 46, pp. 8420-8430, 2007.
[18]         J. G. Kralj, H. R. Sahoo, and K. F. Jensen, "Integrated continuous microfluidic liquid–liquid extraction," Lab on a Chip, vol. 7, pp. 256-263, 2007.
[19]         W. Gaakeer, M. De Croon, J. Van Der Schaaf, and J. Schouten, "Liquid–liquid slug flow separation in a slit shaped micro device," Chemical engineering journal, vol. 207, pp. 440-444, 2012.
[20]         A. Günther, M. Jhunjhunwala, M. Thalmann, M. A.                   Schmidt, and K. F. Jensen, "Micromixing of miscible liquids in segmented gas− liquid flow," Langmuir, vol. 21, pp. 1547-1555, 2005.
[21]         J. Polak and B. C.-Y. Lu, "Mutual solubilities of hydrocarbons and water at 0 and 25 C," Canadian Journal of Chemistry, vol. 51, pp. 4018-4023, 1973.